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Tirzepatide and Semaglutide are two innovative medications that have gained significant attention in the realm of weight loss treatment

Semaglutide is a long-acting GLP-1 receptor agonist with 94% homology to native human GLP-1, engineered for once-weekly dosing and clinically validated for weight loss and type 2 diabetes

The pathogenic link between PsA and T2DM is not yet fully understood, but inflammatory cytokines, particularly TNF and IL-17, are known to impair insulin signaling and promote insulin resistance [61]

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