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GLP-1 Binding The EM structure of the GLP-1 apo receptor (i.e., receptor in the absence of any ligand), shows that the N-terminal domain adopts a closed or inactive conformation, where a cap-like structure blocks access to the peptide binding ( PDB ID 6ln2, Wu et al., 2020, Figure 4a)

But its GI side effect profile is also the most aggressive, with nausea rates reaching 40% to 50% and vomiting rates significantly higher than cagrilintide monotherapy

CrossRef Clinical and Genetic Predictors of Glycemic Control and Weight Loss Response to Liraglutide in Patients with Type 2 Diabetes Artemis Kyriakidou, Angeliki V

No changes in fasting glucose, insulin, HbA1c, IGF-1, cortisol, or thyroid hormones were detected at any dose tested