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This could be due to the technical difficulties of simulating the intestinal microbial community

Establishing cause and effect of medications is difficult due to confounding factors and small sample sizes

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As a co-therapy like in case of combined collagen crosslinking (CXL) and intrastromal corneal ring segment (ICRS) implantation to treat keratoconic eyes, no adverse effect from the riboflavin injections were reported (32)

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