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Proc Natl Acad Sci U S A (1998) 95(1):1149.10.1073/pnas.95.1.114 128 ZhangJGFarleyANicholsonSEWillsonTAZugaroLMSimpsonRJet alThe conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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Use of opioids for an extended period of time may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as symptoms as low libido, impotence, erectile dysfunction, amenorrhea, or infertility

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