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For optimal synergy, combine collagen with vitamin C and light mechanical loading (movement or rehab work) to stimulate collagen crosslinking

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Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )

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B12 supplementation is very safe and side effects are very rare, but supplementation is often required for life