Therefore, future studies are warranted to measure NE, DA, and 5-HT simultaneously and map the neurochemical landscape evoked by tesofensine (and other appetite suppressants) using either GRAB sensors with fiber photometry [65, 66] or classic in vivo microdialysis with capillary electrophoresis
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Safety across the full program was consistently favorable: adverse events, primarily mild headache and gastrointestinal symptoms, occurred at rates comparable to placebo, with no treatment-related discontinuations, no IGF-1 elevation, and no impact on glucose metabolism
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