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However, by the final treatment day the strength of the effect had signs of waning at some doses, which suggested that if treatment were extended efficacy may drop off over time

Hemolytic anemia is the main pathological manifestation of -thal, and hemolysis occurs for two reasons: premature destruction of erythroid precursor cells, and shortening of the lifespan of mature erythrocytes in the circulation ( Anemia in individuals who have -thal is primarily triggered by ineffective erythropoiesis (IE)