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Together, as MTHFR is an important enzyme for folate metabolism which plays critical role in epigenetic as DNA methylation, accumulated evidence showed that global DNA methylation can be associated with MTHFR polymorphism genotypes in both healthy populations and individuals with various diseases

46,49 Sirtuin signaling pathway Sirtuin family proteins play crucial roles in immune aging by regulating mitochondrial function, oxidative stress, and NF-B signaling, thereby maintaining immune homeostasis across various immune cell types

10.1021/acs.jafc.3c01099 53 LuY.ZhangC.SongY.ChenL.ChenX.ZhengG.et al (2023)

Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling