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This activation may be mediated by the free fatty acid receptor 3 (FFAR3

Mild dehydration is common but manageable with intentional fluid intake

[1] In the bloodstream, more than 95% of circulating IGF-1 is not free

Ethics declarations Ethics approval and consent to participate The current study was approved by the Research Ethics Committee of Isfahan University of Medical Sciences (ID: IR.MUI.RESEARCH.REC.1400.037, March 2021)

J Exp Bot 68:17151729 Naranjo-Arcos MA, Maurer F, Meiser J, Pateyron S, Fink-Straube C, Bauer P (2017) Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein