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The result can include: Hollowed cheeks or temples Deeper smile lines and under-eye hollows Skin that looks looser or slightly saggy around the jaw Fine lines that appear more pronounced This isn't unique to GLP-1 medications

These data also suggest a translationally attractive concept: circadian-aligned microbial therapies (for example pairing time-restricted feeding with targeted Bifidobacterium supplementation or fermentable-fiber prebiotics) may more effectively restore bifidobacterial rhythmicity and metabolic function and thereby afford greater protection against MASLD than untimed or ad libitum interventions a hypothesis supported by feeding-timing studies that rescue microbial oscillations and improve hepatic outcomes in rodents

Patients with genetic markers indicating rapid GLP-1 receptor sensitivity may benefit from lower starting doses or slower titration to reduce early adjustment symptoms, including mood shifts

Hasan GM, Anwar S, Shamsi A et al (2024) The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Plans under Medicare Part D and state-Medicaid programs may also cover it, depending on specific criteria