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Building on the mechanisms discussed in Chapter 5.2, such as identity lag, bodyself misalignment, internalized stigma, and autonomydependency dynamics, this section specifies how these processes may influence emotional adaptation, adherence patterns, and expectations during treatment

Phase 2 Obesity Trial (N=338) The key phase 2 randomized controlled trial published in the New England Journal of Medicine enrolled 338 adults with obesity (BMI 30 to 50 kg/m) and randomized them to once-weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, versus placebo over 48 weeks [5]

Oct 2018;41:113-132

IGF-1 also inhibits protein breakdown by downregulating the expression of genes involved in muscle atrophy, such as MuRF1 and MAFbx (Lai et al., 2004)

Kansteiner, Fraiser