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While genes like IFIH1 and TYK2 modulate the response of the immune system to pathogens and inflammatory signals, other genetic factors shape the direct interaction between the host and the environment

Mutation and catastrophe in the aging genome

Another recently discovered therapeutic strategy in ASD is targeting a small GTPase, RhoA, that is involved in cellular cytoskeleton structure and motility [136], and has found to be upregulated in some ASD models while being downregulated in others [34, 137,138,139]

Zheng R, Tao L, Jian H, Chang Y, Cheng Y, Feng Y et al (2018) Nlrp3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter

doi:10.1097/01.pgo.0001028016.32068.b4