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Melatonin further reinforces insulin sensitivity by synchronizing circadian insulin secretion, improving mitochondrial efficiency in hepatocytes and skeletal muscle, and attenuating the nocturnal cortisol overshoot typical in PCOS (226, 227)

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3 There is some evidence that GLP-1 affects glucose utilization by directly stimulating glycogen synthesis in both rat skeletal muscle 4 and rat adipose tissue 5 , at the same time causing an increase in glycogen synthase-alpha

Regarding GLP-1 therapies, the SURMOUNT-1 trial demonstrated tirzepatide's superior efficacy, with participants achieving up to 22.5% total body weight reduction at the 15mg dose