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Thats especially true given the mystery for why people with Type 2 diabetes (for which these drugs were used for many years) did not exhibit much in the way of weight loss

Ishy, P

Improved Overall Health GLP-1 weight loss injections not only help with shedding pounds but also improve overall health by regulating blood sugar, reducing the risk of type 2 diabetes, and supporting cardiovascular health

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It is plausible that the two siblings may carry different GLP1R genotypes: the sister might harbor the rs6923761 AA variant, which is associated with a higher weight loss rate, while the brother may carry the GG or GA variant that weakens semaglutide efficacy