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Due to the non-randomized and observational design of the study, causality cannot be established

8(3): 168181 Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger Tan DX, et al Curr Top Med Chem 2002 Feb

A typical titration schedule begins at 100mcg per dose administered subcutaneously, held constant for 710 days while baseline measurements are collected