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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

The FDA's boxed warning on these medications is there for a reason

Skip it and you risk contaminating a vial worth hundreds of dollars

- Pycnogenol Improves Endothelial Function in Coronary Artery Disease PubMed: Nishioka et al

It says to contact your provider if the sensitivity is severe, lasts beyond twelve weeks, or meaningfully affects quality of life, and notes a provider may temporarily reduce, re-time, or switch the formulation