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In in vitro macrophage polarization models, exogenous -KG significantly increases Arg1 expression and suppresses iNOS expression, and changes in the -KG/succinate ratio are closely associated with the expression of M2-related genes ( in vitro cultured macrophage models, high concentrations of leucine can enhance anti-inflammatory gene expression through mechanistic target of mTORC1 signaling, which is inconsistent with other theoretical views and suggests that its effects are condition-dependent (29)

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The resulting neuronal damage manifests as a spectrum of cognitive, psychiatric, and motor dysfunctions, with long-term consequences for brain structure and function

doi: 10.1093/ajcn/71.6.1421

If a patient is on one of these medications, it is well-known that food passes more slowly through their stomach into their intestines