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By forming bonds with these phosphate groups, magnesium effectively reduces their inherent repulsion (Pasternak et al

doi: 10.1016/j.arr.2021.101481 56 HuWChenYDouCDongS

Published clinical studies report excellent skin tolerance, with no significant irritation or notable allergic reactions at concentrations used in topical formulations (generally 0.01% to 1%)

For retatrutide, the safety database is smaller because the compound is still in Phase 3 trials