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Abnormal gut microbiota in patients with T2DM and obesity promote abnormal intestinal permeability with the development of endotoxemia and systemic complications (Venegas-Borsellino et al

A diet high in processed foods and added sugars can disrupt the delicate balance of the gut microbiome, leading to inflammation and oxidative stress

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Baseline Sleep Quality Individuals with poor baseline sleep quality (light sleepers, frequent wakers, stress insomnia) tend to notice the most dramatic improvement

ICV injection of exendin-9-39 attenuated the anorectic effect of peripheral OXM, further suggesting that OXM-mediated anorexia is produced through a central GLP-1R-dependent mechanism (30)