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(Injecting plain water in large volume would cause cells to swell and rupture due to osmotic imbalance, so sterile water is only given after adding an appropriate amount of solute to make it nearly isotonic

Statistical Analyses Statistical analyses of mean values for multiple comparisons between different groups were made by one-way ANOVA followed by Fisher's test

Methylation and the CopperZinc Axis Dr

Results in trial reports (primary trial results and subsequent secondary publications), and their accompanying Additional file 1, were used as the primary source of information

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