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Since GHK-Cu carries copper, taking too much for too long may be a concern for people with liver issues, copper metabolism concerns, or pregnancy/nursing considerations

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In clinical studies, nasal delivery devices can include: nose droppers, sprays, needleless syringes, breath-powered bi-directional nasal devices, pressurized meter dose inhalers, and pressurized olfactory delivery [8,9,18]

Proton pump inhibitor (PPI) users : Long-term acid suppression decreases protein-bound B12 release

More is not always better with peptides, and some people experience irritation at higher concentrations