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Crucially, oncogenic drivers such as Myc and p53 modulate this flux through epigenetic regulation of core enzymes such as glutaminase, glutamine synthetase and ornithine transcarbamylase, thereby channeling metabolism toward tumor progression

Uveal melanoma is rare (3.75% of all types of melanomas) and occurs as a result of malignant transformation of melanocytes at the choroid of the eyeball

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