rare side effects of semaglutide 💉Ozempic, a drug originally approved to treat type 2 diabetes and now widely used as a weight-loss aid, is at the center mounting legal battles. The manufacturer, Novo Nordisk, faces more A new report estimated that

Alterations in AAs in PBH could also contribute to the significant reduction in 2-aminoadipate and -hydroxybutyrate, biomarkers of diabetes risk and insulin resistance (12, 13, 32)

Therefore, costs could be in the trillions

While these side effects are typically mild to moderate, they can impact patient adherence

The trial anchors are STEP for semaglutide ( NEJM , 2021), SURMOUNT for tirzepatide ( NEJM , 2022), and SURMOUNT-OSA for tirzepatide in sleep apnea ( NEJM , 2024)

The maintenance dose of 2.4mg should be offered alongside a reduced-calorie diet and increased physical activity, NICE said in the final draft guidance