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These biochemical activities are the speciality of the transcriptional co-activators, which are multiprotein complexes that dock on the DNA-binding activators

This finding may contribute in part to the explanation for why the combination of agonists targeting both the GIP and GLP-1 systems has yielded promising results in preclinical models and clinical trials, providing greater body weight loss and better glycemic control than GLP-1R agonism alone (25,5457)

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