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Investigating the effects of GLP-1 receptor agonists on thyroid autoimmunity

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Special property Compared to the native protein sequence, CJC-1295 has four amino acid substitutions which improve protease resistance, and an additional lysine residue at the C-terminus that incorporates a maleimidopropionic acid group

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Overall, existing inhibitors suffer from insufficient selectivity, highlighting the urgent need for LONP1-specific agents developed through advanced approaches such as cryo-electron microscopy and molecular dynamics simulations to expand therapeutic options

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