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If you take metformin, your physician may recommend: More frequent blood glucose monitoring during the first 2 to 4 weeks of MOTS-c use Starting MOTS-c at a lower dose (2.5 mg rather than 5 mg) Watching for signs of hypoglycemia: shakiness, sweating, confusion, rapid heartbeat Potential metformin dose adjustment as MOTS-c's effects take hold Insulin MOTS-c improves glucose uptake in skeletal muscle independently of insulin

doi:10.3390/nu10010041 [DOI] [PMC free article] [PubMed] [Google Scholar] 11.Rolim LC, da Silva EM, Flumignan RL, Abreu MM, Dib SA

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This combination may lead to slowed breathing, increased drowsiness, or delayed recovery all of which are dangerous in a clinical setting