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Oxidation kinetics for roGFP2 WT -PfGrx fusion constructs The in vivo oxidation kinetics from fusion constructs between roGFP2 WT and a variety of glutaredoxins and mutants thereof were shown to correlate very well with the rate constants for the oxidative half-reaction from GSSCys assays in vitro, suggesting that the glutathionylation of the glutaredoxin and not the transfer of oxidation to the fused roGFP2 moiety was rate-limiting under the chosen conditions 15,34,35

Structured observation checklists provided by the therapy team allow parents to record the frequency and quality of target behaviours at home, providing rich real-world data to complement clinic-based assessments

They are involved also in the stimulation of mucin synthesis and in the preservation of gut barrier integrity, inducing TJ assembly

Stability depends on correct handling, including temperature control and avoiding degradation

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