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Previous studies also have demonstrated that oxidative stress reduced neuronal cysteine uptake via EAAC1 dysfunction, leading to impaired GSH synthesis in the mouse midbrain [109]

The proposed mechanism most often cited involves GIP-receptor-mediated effects on adipose insulin sensitivity and possibly on central energy balance, though attribution between the two receptors in vivo remains an area of ongoing study

In the face of foam cell buildup and excessive cell death, efferocytes can become overwhelmed, leading to the loss of atheroprotective effector functions, cell death, and the release of pro-inflammatory DAMPs, which all augment the proatherogenic environment 2

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Injection site reactions Redness, itching, or mild swelling at injection sites is common, especially during the first two weeks