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A glutathione-binding RNA aptamer, selected through SELEX, triggered ROS-mediated apoptosis in MCF-7 breast cancer cells by depleting intracellular glutathione and activating caspase-3, providing a novel strategy for inducing cell death [109]

Lynch J, Jin L, Richardson A, Conklin DJ

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Their potential interactions with both hypothalamicpituitary pathways and peripheral metabolic markers continue to be evaluated, although the mechanistic basis of the blend remains an active area of study