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GLP-1 Receptor Activity, Appetite, and Satiety GLP-1 receptor activation can increase glucose-dependent insulin release, reduce glucagon secretion, slow gastric emptying, and influence central appetite pathways [11]

Caldart F, de Pretis N, Luchini C, Ciccocioppo R, Frulloni L

Xigduo XR - Clinical Pharmacology 12.1 Xigduo XR Mechanism of Action Dapagliflozin Sodium-glucose cotransporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen

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Decades of safety data from diabetes trials show GLP-1 agonists are well-tolerated over extended periods