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Name: tirzepatide surgery Bariatric rates decline as GLP-1 prescriptions rise Tirzepatide for Medical Weight Management
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doi: 10.1038/nmeth.1322 19 FrhbeckGBusettoLDickerDYumukVGoossensGHHebebrandJet al

The dual-agonist mechanism is likely the driving force behind the difference in weight change between treatments

Fat will feel like a pocket & often create a bulge or roll when grabbed, whereas loose skin will be stretchy & thin between the fingers & can be rolled or rubbed against each other with no substance in between

doi: 10.1007/978-1-0716-1566-9_8 20

492 Targeting less conserved substrate binding sites, as opposed to ATP binding sites, might offer advantages in terms of drug specificity, functional regulation, and safety