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This review is therefore structured to provide a novel and unifying perspective

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These findings are similar to data recently published by us in clinical cohorts, with E4 carriers exhibiting relatively higher SCAs and lower LCAs with AD even at the pre-clinical stages compared to controls and other APOE genotypes (Huguenard et al., 2022)

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They are naturally occuring in the body, signaling molecules that dictate major physiological processes like tissue repair or metabolism