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When this barrier becomes compromised, a condition often referred to as leaky gut may develop

Alternatively, oral capsules are available but have significantly lower bioavailability

These symptoms are mediated by the hormones of the adrenal cortex, especially cortisol, released as a result of signals from the HPA axis

This is especially relevant for people with hormone optimization protocols who may be taking thyroid medications, hormone replacement therapy, or other compounds that depend on consistent absorption patterns

Biochem Genet 55:212222 Siebert L, Headrick S, Lewis M, Gillespie B, Young C, Wojakiewicz L, Kerro-Dego O, Prado ME, Almeida R, Oliver SP, Pighetti GM (2017) Genetic variation in CXCR1 haplotypes linked to severity of streptococcus uberis infection in an experimental challenge model