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(3) GDF15 elevation through BAT-secreted integrated stress responses

A Master Protocol to Investigate the Efficacy and Safety of LY3437943 in Participants Without Type 2 Diabetes Who Have Obesity or Overweight (includes OSA + knee OA substudies)

Characteristics in People with T2D Table 2 shows the characteristics of the people with a record of T2D who initiated semaglutide (Ozempic)

Injection site reactions occurred in 1015% of participants, slightly more than with semaglutide alone

This is well documented in clinical literature and is one reason smaller, more frequent meals tend to work better than three large ones