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It is clear that neither X-ray crystallography nor cryo-EM can obtain a high resolution structure for intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) because of a very simple reason: unlike ordered, well-folded proteins and domains, IDPs/IDRs do not adopt a single, stable three-dimensional structure

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Some highly sensitive receptor binding assays may require even higher purity to avoid interference from peptide-related impurities

A pending submission is not an approval, and cagrilintide may not be prescribed, dispensed, or sold for human use

TRT is not a set-it-and-forget-i