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Sterile inflammation in the liver

It's important to consider these outcomes when choosing between the two treatments

Beyond vesicular signaling, specific stromal subpopulations such as THBS2 CAFs promote resistance through the paracrine secretion of factors like COL8A1, which can induce epithelial-mesenchymal transition (EMT) and activate the PI3K/AKT axis in tumor cells, thereby blocking the cytotoxicity of agents such as oxaliplatin [104]

Orexin-A and B also inhibit depolarization-stimulated 5-HT release [80]

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