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[11] Function [edit] NADPH provides the reducing agents, usually hydrogen atoms, for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species (ROS), allowing the regeneration of glutathione (GSH)

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Under oxidative stress, ROS act as major metabolic signals that enhance FoxO activation through multiple pathways: suppression of PI3K/Akt, activation of AMPK, JNK, and p38 MAPK, and deacetylation via SIRT1 and HDACs (Zhang H

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