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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

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Antioxidative und entzndungshemmende Wirkung GHK-Cu wirkt als Fnger freier Radikale : Fngt Hydroxylradikale (OH) ein Hemmt die Lipidperoxidation Stimuliert die endogene antioxidative Abwehr (SOD, Glutathionperoxidase) Im entzndungshemmenden Bereich moduliert es die NF-B-Signalgebung , den wichtigsten Transkriptionsfaktor der Entzndungsantwort

Part 2-Nonrespiratory Conditions

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