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Breg cells are believed to regulate the induction of autoimmune disease by inhibiting the differentiation of Th1 and Th17 cells, while promoting the proliferation of Treg cells [74]

Furthermore, FOXO4-DRI targets the tumor suppressor p53, a crucial protein, which may lead to various side effects in clinical trials 37

Additionally, activating the SIRT1/Nrf2/p62 pathway can promote the healing of diabetic foot ulcers, possibly mediated by autophagy-dependent ferroptosis ( Together, the diverse roles of SIRT1 across multiple disease types underscore its significance as a promising therapeutic target

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doi: 10.1128/IAI.01008-08 167 WarrenJ