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Up to now, GLP-1RA has been approved by FDA for marketing including liraglutide, dulaglutide, semaglutide, lixisenatide, albiglutide, and exenatide

Zinc deficiency has been linked to impaired night vision and increased risk of AMD

10.1038/s41598-017-12597-9 17 AokiN.Jin-noS.NakagawaY.AsaiN.ArakawaE.TamuraN.et al (2007)

It is established cardiac pharmacology, documented in the NEJM paper: "Glucagon and GLP-1 can exert positive chronotropic and inotropic effects on the heart." GLP-1 also contributes: GLP-1 receptor activation by itself produces a modest chronotropic effect this is why semaglutide and tirzepatide raise heart rate by 14 bpm

Rescue therapy was used in 18% of patients treated with JANUVIA 100 mg and 40% of patients treated with placebo