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also discussed the biological plausibility of GLP-1 RAs influencing thyroid cells, citing preclinical evidence of GLP-1 receptors in thyroid tissue

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1 mg NDC 0169-4136-02List 413602 OZEMPIC (semaglutide) injection For Single Patient Use Only 2 mg/1.5 mL (1.34 mg/mL) Prefilled pen Pen delivers doses in 1 mg increments only For subcutaneous use only Use OZEMPIC once weekly Contains: 2 OZEMPIC pens, 4 NovoFine Plus 32G needles, Product Literature

The reasons could have been multipronged ranging from toxic accumulation of folate and B12 in patients of diabetic nephropathy with low GFR or competitive inhibition of TMP and TPP transport at the level of RFC1 transporter by high dose folate at key sites such as the kidney and vascular cells thus adversely affecting sharing of thiamine between tissues rich in thiamine and those deficient in it [183]