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Patients who experience palpitations beyond 8 weeks at a stable dose should undergo formal cardiac evaluation including ECG and Holter monitoring to rule out arrhythmia unrelated to normal GLP-1 adaptation

Timing based on disease severity and peptide protocol intensity

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Convincing improvement in OA In a 2024 paper published in T he New England Journal of Medicine, Bliddal and colleagues enrolled 407 patients with knee OA and obesity in a double-blind, randomized, placebo-controlled trial, called STEP-9, at 61 sites across 11 countries