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Akindehin, S

Combining ferroptosis-inducing agents with already available therapies, such as immune checkpoint inhibitors and targeted kinase inhibitors, may provide synergistic effects and improve patients clinical outcomes and survival [134]

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I also observed a worsening of pre-existing POTS symptoms a condition that, in hypermobile Ehlers-Danlos Syndrome, is not incidental but mechanistically downstream: a recognized consequence of defective extracellular matrix that can produce peripheral venous laxity, impaired lower-extremity vasoconstriction, chronic hypovolemia, and the compensatory hyperadrenergic state that characterizes the neuropathic POTS phenotype

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