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Uric Acid Production as a Target of Therapy in Patients With Gout In the catabolism of purines, uric acid generation by the enzyme xanthine oxidase (that also has xanthine dehydrogenase activity) ( Figure 1 - 2 ) highlights the key therapeutic mechanisms of action of the xanthine oxidase inhibitors allopurinol and febuxostat ( Pharmacologic Urate-Lowering Therapy )

Grenzi M, Buratti S, Parmagnani AS, Aziz IA, Bernacka-Wojcik I, Resentini F, imura J, Doccula FG, Alfieri A, Luoni L, Ljung K, Bonza MC, Stavrinidou E, Costa A (2023) Long-distance turgor pressure changes induce local activation of plant glutamate receptor-like channels

From the practitioners perspective it may appear advantageous to withhold primaquine therapy, particularly if patients are not requesting it