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Glutamine supplementation is a strategy used in situations of intense catabolism, in which there is a decrease in the synthesis and release of glutamine by the skeletal muscle and increased uptake by other organs (kidneys and liver), such as in prolonged and intense exercises, as well as in overtraining syndrome [125, 126]

Such microglial transitions likely involve epigenetic reprogramming induced by MIA, coupled with metabolic adaptations in response to subsequent stress

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Supplementing with Vitamin D can sometimes improve these symptoms, especially in cases of marked deficiency

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