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Tirzepatide was associated with greater HbA1c reductions and body weight reductions than placebo therapy

Bacterial byproducts from the small intestine enter the bloodstream and can drive systemic symptoms including fatigue, brain fog, joint pain, rosacea, and mood disturbances

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By contrast, hyperplastic WAT expansion distributes excess fat among newly formed small adipocytes, reducing hypoxic stress on the fat depot and the subsequent inflammation by decreasing the number of hypertrophic adipocytes [45, 46]