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Hypoglycemic drugs such as metformin, SGLT2i, DPP-4i, GLP-1RA, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have also shown beneficial effects against tubular injury, potentially slowing the progression of the DKD, and thereby protecting the kidney

Preliminary findings from the NCT05369390 trial suggest that oral amycretin may offer superior efficacy compared to OW semaglutide for the treatment of obesity [127]

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Furthermore, NAC acts as a direct source of sulfur, helping to replenish the body's sulfate stores required to execute the sulfation pathway of Phase II detoxification