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Severe Systemic Fatigue: NAC's ability to break disulfide bonds in microclots helps restore proper capillary blood flow, ensuring that oxygen and nutrients can reach oxygen-starved muscle tissues, thereby reducing systemic exhaustion

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Overall, the proteomic data indicated that semaglutide effectively mitigated hepatic lipid deposition and key pathways related to fatty acid/lipid protein signalling and fibroblast proliferation ( Figure S11 ), further supporting our histological and single-cell RNA sequencing findings