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These data are protected by a confidentiality agreement with the study sponsor, Zambon S.p.A., Italy, due to their ethically and commercially sensitive nature

12.2 Pharmacodynamics In vitro, lamotrigine inhibited dihydrofolate reductase, the enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate

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Adequate fiber intake, hydration, and sometimes fiber supplementation address this for most researchers

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