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Arrone, who has led numerous clinical studies on GLP-1 medications and other obesity treatments, also emphasized the need for resistance training to protect muscle mass during weight loss because muscle loss happens more often when people eat very little and lose weight fast

Among individual drugs, liraglutide has been noted to carry a relatively higher risk of nausea and vomiting

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Recent findings indicate that the anti-inflammatory effects of GLP-1RAs, mediated through GLP-1R in CNS neurons (268) and intrahepatic lymphocytes (269), play an important role in their antiatherogenic actions

GLP-1R causes a reduction in hepatic steatosis and inflammation and increases fat metabolism mediated by increasing hepatic insulin sensitivity [52,53,54]